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Selective flexible packaging pathways of the segmented genome of influenza an endemic Imaging of IAV vRNAs and vmRNAs We studied vRNP bundling in human A549 cells contaminated with the prototypic seasonal influenza A/Panama/2007/ninety nine virus (H3N2) at a single-telephone level after 10 h.p.i. (MOI 5). To visualise all vRNAs and foremost viral mRNAs (vmRNAs), we utilized a multiple sequential FISH assay30 (MuSeq-FISH, see ‘strategies’) very similar to a these days posted procedure31. as much as 12 MuSeq-FISH cycles had been carried out, each and every simultaneously concentrated on two RNA species with probe sets coupled to two distinct fluorophores (Atto550, Fig. 1a; STAR635P, Supplementary Fig. 1, Supplementary table 1). After each of the cycles, probes have been removed via formamide treatment (see ‘methods’; Supplementary Figs. 2–4). To reduce talents false-effective alerts, every vRNA became focused twice alongside the cycles, as soon as with Atto550 (Fig. 1a) and as soon as with STAR635P-labelled probe units (Supplementary Fig. 1). Cycles for the first and second labelling of a given vRNA had been randomly chosen among the many 12 cycles, and dissimilar between triplicates to exclude a potential bias introduced by way of the order of staining. We excluded vRNA spots followed most effective for one probe set from extra analysis. Fig. 1: Localisation of viral RNA (vRNA) and vmRNA in A/Panama-infected A549 cells. a Viral genomic RNAs were stained by using fluorescence in situ hybridisation (FISH) 10 h.p.i. (MOI 5). To cowl all vRNAs and main vmRNAs, 12 cycles of FISH labelling were carried out. alongside these cycles, each vRNA was focused twice, once with Atto550 (shown here) and once with STAR635- (Supplementary Fig. 1b) labelled probe sets (for particulars see textual content). b Immunofluorescence staining of NP. DAPI (four′,6-Diamidin-2-phenylindol) labelling turned into performed to exclude nuclear vRNA spots for further colocalisation analysis. c All primary unspliced vmRNAs were stained. photos symbolize max z projections. The intensities of pictures have been scaled in keeping with the corresponding photographs taken after probe removal through formamide. Scale bars correspond to 10 µm. consultant images of four independent experiments are proven. Microscopic evaluation confirmed that the in situ staining patterns of vRNAs and of NP, as detected through an antibody, have been almost similar, demonstrating the specificity of FISH probes for vRNP segments (Fig. 1b, α-NP + vRNA). high diploma of colocalisation was observed for all vRNA segments (Fig. 1a, overlay, white colouring). We proven probe specificity of A/Panama probes concentrated on A549 cells infected with the influenza B/Lee virus (see Supplementary Fig. 5). Any fluorescence signal bobbing up even from unspecific binding of FISH probes could not be detected. poor consequences for these probes have been also got for mock-infected A549 cells. To additional determine probe specificity, we in comparison the intracellular distribution of vRNAs with that of all main viral mRNAs (vmRNAs) (Fig. 1c). Cytosolic vmRNA spots didn’t tremendously colocalise with vRNA (Fig. 1 and Supplementary Fig. 1) and with every different (see beneath). For greater details on imaging of vmRNAs and viral cRNAs, see Supplementary note 1. We analysed a complete of 69 A/Panama-contaminated cells, yielding more than three.9 × a hundred and five vRNA spots, every of which corresponded to the detection of a single RNA phase (Fig. 2a). Nuclear vRNA spots had been excluded for analysis for a few factors: (i) low quantities of segments present in the nucleus (Fig. 1), (ii) incomplete vRNAs produced interior the nucleus and detected by FISH may also no longer be able to interacting with other segments and (iii) bundling is presumed to take vicinity within the cytosol29. in step with a old report32, we followed phone-to-phone variability in the absolute number of individual segments and within the normalised variety of particular person segments as printed with the aid of the frequency distribution of selected segments (Supplementary Fig. 7) and statistical analysis (Fig. 2, legend, Bartlett verify), respectively. however, for almost all of cells, at the particular person phone level, a balanced ratio between the eight vRNA segments turned into accompanied (Fig. 2a) with no large difference between the segments (ANOVA, F look at various, for details see legend to Fig. 2). Fig. 2: Viral RNA (vRNA) abundances in A/Panama-contaminated A549 cells 10 h.p.i. a Relative abundances of all vRNA segments per telephone as measured via fluorescence in situ hybridisation (FISH). For each and every of the measured cells (n = sixty nine from four unbiased experiments), the variety of spots that had been detected changed into counted and normalised to the whole variety of spots per phone. The colouring scheme is the same as in Fig. 1. b facts shown in a in a Tukey boxplot illustration. higher bound of field, centre and decrease sure of the field represent the 75th percentile, the 50th percentile (median) and the 25th percentile, respectively. higher and lower whiskers characterize the maxima and minima of the boxplots showing the respective biggest or smallest price within 1.5× interquartile latitude above the seventy fifth or beneath the twenty fifth percentile (bounds of box). In all, 12.5% (red line) corresponds to the anticipated fraction for each and every vRNA in a uniform distribution. For the segments, there isn’t any large difference (ANOVA, F test, one-sided, α = 0.05) between the cells (P > 0.999). The utility of ANOVA requires Gaussian distribution (fulfilled, see Supplementary Fig. 7) and the equal variability (typical deviation) for the segments. despite the fact, the Bartlett test (one-sided, α = 0.05) shows that the variability of the individual segments is significantly distinct (P > 0.0001). The Kruskal–Wallis look at various doesn’t presuppose homogeneity of variability, but concurs with the F look at various within the outcome, i.e., no massive ameliorations (one-sided, P > 0.999). source information are supplied as a source statistics file. usual, the population-averaged fractions of the quite a few vRNAs had been equal, with every acting at about 12.5% (Fig. 2b; information, see legend). This consents with qRT-PCR measurements at the telephone population stage (Supplementary Fig. eight) displaying that the expression ranges of the distinctive vRNA species were equivalent. We also studied vRNA formation in A549 cells infected with A/Mallard/439/2004, a low-pathogenic avian IAV it really is dicussed under. analysis of rank and segment composition of MSCs to relate the vRNA indicators to each other, we originally conducted a colocalisation analysis binning two or more vRNA spots inside a cylinder of radius 300 nm and height a thousand nm into one MSC (Supplementary notice 2). although the dimension of remoted vRNP complexes varying in length between 50 and 150 nm33 is smaller, these cylinder dimensions had been chosen for two factors: the decision limit of confocal fluorescence microscopy being roughly 200 nm34 in the x–y route, and findings via Chou et al. and Lakdawala et al.28,29 who have used a radius of 255 nm in the x–y course similar to our cylinder radius. Our 3D-stack acquisition within the z route changed into carried out with four hundred-nm steps due to the decrease resolution within the z direction of confocal microscopy, which is the explanation for determining a height of one thousand nm for colocalisation analysis. significantly, a cautious evaluation of the informative value of this evaluation involving high-resolution prompted emission depletion (STED) microscopy offered strong aid for the validity of this approach (see below). All nuclear spots had been excluded on the premise that segment bundling takes location within the cytosol29, as tested with the aid of the ample presence of MSC of lessen ranks, and predominant colocalisation of vRNA spots during this compartment (Fig. 1). In all, i.e., 69 cells, a complete of about 1 × 105 MSCs had been discovered, 69% of which represented multimeric complexes. We discovered most effective in below 5% signals for the presence of two, but not extra copies of the identical species. however, in view of the optical decision finished, our strategy doesn’t allow to handle accurately no matter if numerous copies of a phase are latest in an MSC. moreover, Chou et al.35 have shown that no longer all selected FISH probes bind to a phase of purified viruses. for that reason, we can’t assume that all of the FISH probes we have used for a specific section will bind. In specific, the accessibility of a section can be moreover impacted in contaminated cells, and the presence of multiple reproduction of the equal phase may be ignored. then again, an earlier document on competition between vRNAs that possess the equal packaging sign, however encode diverse reporter genes, counseled inefficient incorporation of varied copies of the same vRNP in a single MSC36. actually, on account that all feasible mixtures of vRNPs (see Supplementary strategies and Supplementary Eqs. 1–3), the random packaging model predicts that ninety eight% of the MSCs would include two or greater copies of a definite section species. therefore, the followed low incidence of two segment copies inside one MSC is in line with a selective vRNP packaging model with a managed phase composition of MSCs. based on these findings and former reports10,11,12,13,28,29,35, we considered that only one reproduction of each and every vRNA segment is packaged into an MSC and ranked eight because the optimum rank of MSCs comparable to an IAV genome with an entire vRNP set. In Fig. three, the frequency distribuiton of MSC ranks (a–d), the whole variety of segments in infected cells (e–h) and the number of segments now not concerned in MSC formation (i–l) are proven. typically, we accompanied a marked u-formed frequency distribution of MSC ranks with both maxima representing free segments (monomers, rank 1) and octameric complexes (rank eight), respectively (Fig. 3a, b, stuffed bars). ‘mobile 18’ illustrates this in an exemplary way (see ‘Rank Distribution’, Fig. 3b, crammed bars). tremendously, these aspects and peculiarly the u-formed distribution of MSC ranks described above had been also observed when averaging over all cells (Fig. 3a), with only a number of cells deviating from this pattern (see below). These rank distributions are vastly distinctive from a uniform distribution (Chi-square look at various, α = 0.05; P < 0.0001). The amounts of S1–S8 segments (Fig. 3e, ‘total Segments’) were just about equal, other than small, but colossal ameliorations between S2 and S8 and S5 and S8 (records, see legend to Fig. three) (see ‘discussion’). Fig. three: Distribution of MSC ranks in A/Panama-infected A549 cells after 10 h.p.i. a complete of 3.9 × a hundred and five diverse segment spots had been detected in A/Panama-contaminated A549 cells and binned into about 1 × a hundred and five MSCs. The frequency distributions of MSC ranks ( a – d , ‘Rank Distributions’, crammed bars: ‘MSC counts’, empty bars: ‘section counts’), of all segments S1–S8 occurring in a phone ( e – h , ‘complete Segments’) and of free, i.e., monomeric segments, i.e., rank 1 ( i – l , ‘Free Segments’) are proven. Frequency distributions for all 69 cells ( a , e , i , ‘All Cells’) and exemplary for a single phone (e.g., ‘phone 18’ b , f , j ). Frequency distributions for cells wherein selected segments appeared in unusually low quantities: counts had been low for S1 and S8 in ‘mobilephone 23’ c , g , okay , and for S8 in ‘cellphone 29’ ( d – l ). In a , values are proven as mean ± s.e.m. facts for ‘total Segments’: a dissimilar assessment of potential through Tukey look at various (one-sided, α = 0.05) displays the following significant alterations between segments: a S2–S8 and S5–S8 (P = 0.041; *P ≤ 0.01); source statistics are provided as a source statistics file. MSCs of high rank made up the majority of the full segments found (Fig. 3a, b, empty bars), and the number of solitary segments (rank 1) become low (Fig. 3i, j) showing that the majority of each phase assembles into MSCs. This statement strongly means that interactions between the segments direct against the formation of high-rank MSCs. For a few cells (mobilephone 23 (Fig. 3c) and cell 29 (Fig. 3d)), rank distributions had been significantly different from those in Fig. 3a and b (Chi-square test, α = 0.05; P < 0.0001), which can also provide clues for MSC assembly. primarily, the quantities of section eight (telephone 23 (Fig. 3g) and cellphone 29 (Fig. 3h)) and phase 1 (cellphone 23 (Fig. 3g)) have been low in comparison to the closing segments (see ‘dialogue’). previous studies28,29 have said an increase in the frequency of complexes with increasing rank in contaminated cells. At a first look, this appears to be in distinction to the u-formed distribution accompanied right here. youngsters, this obvious discrepancy to the prior reports can with no trouble be reconciled via the inherent limitation to unravel handiest a optimum of 4 diverse segments. because of this, due to the fact no complexes of rank 5 or larger can be identified, MSCs accompanied as rank 1–4 also include complexes ranked greater than rank 4, leading the authors to indicate a continuous enhance in the frequency of complexes with expanding rank. subsequent, we focused on the phase composition of MSCs at ranks 2–7 (Fig. 4), which most likely signify intermediate complexes of the assembly pathway (see beneath). A spectacular discovering changed into that for any given intermediate rank, there was not a single specific segment composition of high abundance, but a number of, more quantitative than qualitatively preferred, partly overlapping section mixtures. This remark shows a constrained variability of certain interactions between the vRNPs, but argues towards a strict, non-variable sequence of vRNP interactions consistent with recent experimental and modelling reports14,37,38. within the latter case, we would have anticipated a single different MSC composition to stand out per MSC rank. Fig. 4: specific phase mixtures at intermediate MSC ranks after 10 h.p.i. each subplot indicates the total relative counts of MSCs of each rank containing specific mixtures of segments for all the 69 analysed cells (‘All Cells’ a ) and exemplary single cells (‘Cells 18, 23 and 29’ b – d , see additionally Fig. 3). Listed are the compositions of segments of the 5 most considerable complexes of each and every complex rank (containers). to relate frequencies to the overall counts of the MSCs of the particular rank we check with Fig. 3 (left column). For more advantageous visualisation, records are normalised to the most plentiful MSC of the respective rank. source records are provided as a supply statistics file. in an effort to get a first impression of the dynamics of MSC formation, we analysed compositions of MSCs after 6 h.p.i. (MOI 5). The frequency distribution of the accompanied ranks of MSCs in the cytosol 6 h.p.i. (Supplementary Fig. 9) showed a left-peaked form. it is obvious that the higher ranks at the present after infection are most effective latest in small amounts. A evaluation with the results acquired 10 h.p.i. (Fig. 3a) indicates the dynamic character of the formation of the MSCs. although extra investigations are required, one reason for the reduced frequency of excessive-rank MSCs can be as a result of the lower number of segments per phone (three.1 × 103 (6 h.p.i.) vs. 5.6 × 103 (10 h.p.i.)). vRNP segments in intact IAV virions To examine the vRNP composition of mature A/Panama virions via MuSeq-FISH, virions current in virus shares had been allowed to bind to the surface of human A549 cells on ice adopted by way of instant chemical fixation. curiously, the frequency distribution of MSCs in A/Panama virions became naturally diverse from that found in A/Panama-contaminated cells being shifted to MSCs of excessive rank (Fig. 5). indeed, MSCs of rank 8 composed of the eight distinctive vRNP segments represented the most ample fraction (46%), followed by way of rank 7 (27%) and rank 6 (17%). This finding helps outdated observations implicating a mechanism that ensures a preferential incorporation of MSCs of high ranks into virions. Nakatsu et al.39 applied scanning electron microscopy tomography to diverse influenza A and B strains and confirmed that as a minimum eighty% and in some instances even one hundred% of virions contained an entire genome arranged in the ‘7 + 1’ pattern. Reverse genetics tactics have proven that deletions or mutations in a packaging signal sequence of a single vRNA can steer clear of the incorporation of other vRNPs into virions or virus-like particles2,14,forty. Very possible, the dense arrangement of vRNPs in excessive-rank MSCs kinds a floor favouring focus and preferential incorporation of such complexes into assembling viruses. youngsters, in contrast to Nakatsu et al.39, our results display that incorporation of comprehensive 8-rank MSCs into a/Panama virions is not ideal in any respect, accomplishing handiest forty six%. We surmise that the fraction of virions with an entire set might also range reckoning on the strain of IAV41 and, most likely, the class of host cellphone involved. Fig. 5: Viral ribonucleoproteins (vRNP) composition of intact A/Panama virions. Virions have been certain to A549 cells, and consequently, virus-telephone complexes were fixated. Viral RNA (vRNA) segments (S) were stained by fluorescence in situ hybridisation (FISH) with Atto550-coupled FISH probes. a Fluorescence images signify max z projections. hues are identical to Fig. 2. records were acquired from three impartial experiments. Scale bar corresponds to 10 µm. b Histogram of all detected spots and their respective MSC ranks, equal formatting as Fig. three, black bars. c MSC distribution for ranks 5–7, equal formatting as Fig. four. Bars symbolize the number of observed MSCs of the respective combination. N = 1653 spots. supply facts are provided as a supply information file. MSC assembly under non-permissive IAV an infection all of the experiments described above check with a permissive infection of human A549 cells through the human A/Panama virus of the H3N2 subtype42. To gain insights into MSC formation in a non-permissive infection, we contaminated A549 cells with A/Mallard/439/2004 (Supplementary Fig. 10), a low-pathogenic avian IAV of the equal subtype that we previously confirmed to trigger abortive infections in these hosts42. apparently, the analysis of fifty four cells published a heterogeneity of the relative frequency of segments and complexes in particular person cells (Fig. 6a, b, see also legends for information). A greater surprising commentary turned into the robust disruption of MSC formation, especially excessive-rating ones (Fig. 6c). The left-hand-sided, monotonically lowering frequency distribution sample of MSC ranks for the avian virus sharply contrasted with the u-fashioned distribution we observed in permissive infections. The abundance of MSCs of rank 3 and higher changed into notably low pointing to extreme perturbation of vRNP bundling already within the early section. a possible explanation for the left-hand-sided frequency distribution sample may be the low presence of segments being vital for MSC meeting (Fig. 6a–c). Fig. 6: Viral RNA (vRNA) and MSC rank abundances in A/Mallard-infected A549 cells 10 h.p.i. a Relative abundances of all vRNA segments per cellphone as measured by using fluorescence in situ hybridisation (FISH). For each and every of the measured cells (n = fifty four from three impartial experiments), the number of spots that had been detected become counted and normalised to the overall number of spots per phone. The colouring scheme is the same as in Fig. 1. b facts proven in a in a Tukey boxplot representation. higher sure of field, centre and reduce sure of box symbolize the 75th percentile, the 50th percentile (median) and the 25th percentile, respectively. upper and lessen whiskers represent the maxima and minima of the boxplots displaying the respective greatest or smallest price inside 1.5× interquartile latitude above the 75th or under the 25th percentile (bounds of container). In all, 12.5% (red line) corresponds to the expected fraction for each vRNA in a uniform distribution. For the segments, no massive change (ANOVA, F examine, one-sided, α = 0.05) between the cells become discovered (P > 0.999). The Bartlett check (one-sided, α = 0.05) suggests that the range of the individual segments is tremendously distinct (P > 0.0001) (see additionally legend to Fig. 3). The Kruskal–Wallis check doesn’t presuppose homogeneity of variability, but concurs with the F examine within the outcomes, i.e., no giant transformations (one-sided, P > 0.999). source information are provided as a source records file. c – e a total of 2 × one zero five distinctive phase spots have been detected in A/Mallard-contaminated A549 cells and binned into about 9 × 104 MSCs. The frequency distributions of MSC ranks ( c (stuffed bars: ‘MSC counts’, empty bars: ‘segment counts’)), of all segments S1–S8 occurring in cells d and of free segments, i.e., rank 1, e are shown. Values are shown as suggest ± s.e.m. distinctive assessment of potential by way of Tukey test (one-sided, α = 0.05) displays here gigantic modifications between segments d : S2–S4, S2–S5, S2–S8, S3–S8, S4–S7, S5–S7 and S7–S8 (P between 0.0001 and 0.0137; *P ≤ 0.01; **P ≤ 0.001; ***P ≤ 0.0001). supply statistics are supplied as a source statistics file. The reason for this commentary wants future clarification. we’ve lately proven that replication of the avian A/Mallard/439/2004 virus in A549 cells is attenuated by way of three orders of magnitude at seventy two h.p.i. in evaluation to A/Panama/2007/9942,forty three. We had been able to show that each viruses enter A549 cells with an identical efficiency, and that mRNA from each virus strains accesses the translational equipment with similar efficiency. interestingly, A/Mallard an infection in human cells was characterised by means of decreased M1 production and impaired nuclear export of NP, which may additionally have an effect on the nuclear export of and interactions between vRNPs. therefore, we accept as true with it possible that defects followed for avian vRNP bundling in human cells are led to with the aid of disturbances within the ratios of attainable phase species in the cytosol. besides the fact that children, additionally in this case, further investigations are necessary, including greater finished analyses of bundling of avian IAV vRNPs in human and avian cells throughout a few different time points publish infection for a validated conclusion. additionally, our fresh consequences may additionally also indicate that standard MSC meeting may additionally not handiest depend on vRNP–vRNP interactions, but is co-regulated via host-mobile components. We confirmed in a comparative quantitative proteomics strategy a differential legislation of a couple of host proteins in accordance with A/Panama versus A/Mallard infections in A549 cells42. despite the fact, putative roles for these components within the genesis and packaging of vRNPs continue to be to be investigated. Reliability of colocalisation evaluation we’re aware that colocalisation of segments and their project to the equal MSC might in some situations be compromised by means of the optical resolution limit. with the intention to validate the analysis and respective conclusions on the composition of MSCs, we conducted a couple of manage experiments. First, as a terrible manage of the algorithm, colocalisation of spots of two superimposed copies of the identical picture was analysed, whereby these two copies have been rotated by ninety° against each different. As anticipated, colocalisation became very low. The highest rank of MSCs observed changed into 2, with below 1% of the spots of 1 photo colocalised with spots of the other photo circled by way of 90°. Secondly, we investigated colocalisation of vmRNA species making use of the same parameters used for analysis of vRNP colocalisation. Most generally, we followed monomers and dimers (Supplementary Fig. 11), however complexes of better ranks have been infrequent. The fact that vRNAs and vmRNAs exhibited diverse patterns of (co)localisation confirmed that probes are certain for the respective RNA species, and suggests that the photo analysis accurately assigned spots to complexes. Thirdly, the use of the centre of mass for every MSC, the gap of every spot from the centre of mass was calculated for x- and y coordinates and plotted in a histogram (Supplemetary be aware 2, Supplementary Equation 4 and Supplementary Fig. 12). Most segments confirmed a distribution with a marked height exceedingly near the centre of mass (25–60-nm distance). besides the fact that children, distances have been still inside the cylinder radius (300 nm, see above) that allowed colocalisation to be detected. finally, to check the confocal photo-based mostly MSC analysis extra, we performed super-decision multicolour STED microscopy (STED)forty four with a resolution of 79 nm for a specific set of segments (Supplementary Fig. 13). The major fraction of spots colocalising with other spots as determined with the aid of confocal microscopy was also colocalising at the decision level of STED. eventually, as shown above, the frequency distribution of MSC ranks in contaminated A549 cells turned into very distinct between A/Panama and the low-pathogenic avian A/Mallard virus. trade-tuition Cooperative analysis facilities application (IUCRC)
countrywide Science foundation Directorate for Engineering
Industrial Innovation and Partnerships Directorate for desktop and advice Science and Engineering Directorate for Geosciences Directorate for Social, Behavioral and financial Sciences
Preliminary suggestion Due Date(s) (required) (due by means of 5 p.m. submitter’s native time):
July 07, 2020
September sixteen, 2020
March 10, 2021
2nd Wednesday in March, yearly Thereafter
September 08, 2021
second Wednesday in September, yearly Thereafter
Preliminary proposals are required ahead of submission of planning provides. Submitters looking for a waiver of the planning furnish stage should submit the waiver request as a preliminary concept.
Full notion goal Date(s):
September 08, 2020
December sixteen, 2020
June 09, 2021
2nd Wednesday in June, yearly Thereafter
December 08, 2021
2nd Wednesday in December, yearly Thereafter
vital assistance AND REVISION NOTES
Preliminary Proposals are required most effective for Planning offers and Planning provide waivers.
A Planning grant has a period of as much as 365 days and the award measurement has been increased from $15,000 to $20,000.
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summary OF program requirements
industry-school Cooperative research centers program (IUCRC)
Synopsis of program:
The IUCRC software catalyzes leap forward pre-competitive research by enabling close and sustained engagement between business innovators, world-category educational groups, and government organizations. IUCRCs help trade companions and govt businesses connect at once and correctly with university researchers to achieve three fundamental objectives: 1) behavior excessive-have an impact on research to fulfill shared and critical industrial wants in groups of all sizes; 2) increase U.S. global management in driving ingenious technology construction, and three) identify, mentor and strengthen a diverse, incredibly knowledgeable science and engineering body of workers.
The IUCRC program gives a structure for tutorial researchers to conduct primary, pre-aggressive research of shared hobby to trade and executive organizations. These groups pay membership costs to a consortium in order to collectively envision and fund research, with as a minimum ninety% of Member cash allotted to the direct expenses of these shared research tasks.
IUCRCs are shaped around research areas of strategic activity to U.S. business. business is defined very largely to encompass businesses (gigantic and small), startups and non-profit corporations. important Investigators form a center around emerging research topics of latest research pastime, in a pre-aggressive area however with clear pathways to utilized analysis and industrial construction. trade companions join at inception, as an current middle grows or they encourage the creation of a new center by recruiting tuition partners to leverage NSF assist. govt agencies take part in IUCRCs as participants or by using partnering without delay with NSF on the strategic stage.
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a hit IUCRCs require:
A able research/management team with an entrepreneurial frame of mind;
Universities, college, and students drawn to undertaking analysis of hobby to trade;
A neighborhood of business companions in search of pre-aggressive, use-inspired research tasks.
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Prakash G. Balan, IUCRC application Director, Directorate for Engineering,
electronic mail: firstname.lastname@example.org
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relevant Catalog of Federal home assistance (CFDA) number(s):
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Estimated variety of Awards:
2 to eight full core awards and four to 6 Planning supply awards annually.
predicted Funding volume:
individual award sizes (total costs):
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$a hundred and fifty,000 per year for section I
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$one hundred fifty,000 per 12 months for part II+
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notion education and Submission guidelines
A. concept coaching guidelines
Letters of Intent: no longer required
B. Budgetary counsel
oblique charge (F&A) obstacles:
Membership fees received via the center are considered software revenue. at least ninety% of the IUCRC software earnings ought to be used to aid direct charges of the analysis, and up to 10% could be used to assist indirect costs.
NSF award funds are area to an institution’s federally-negotiated indirect charge cost. See particular Award conditions.
different Budgetary boundaries:
other budgetary limitations observe. Please see the complete textual content of this solicitation for further assistance.
C. Due Dates
Preliminary suggestion Due Date(s) (required) (due through 5 p.m. submitter’s native time):
July 07, 2020
September 16, 2020
March 10, 2021
2nd Wednesday in March, yearly Thereafter
September 08, 2021
2nd Wednesday in September, annually Thereafter
Preliminary proposals are required earlier than submission of planning delivers. Submitters in quest of a waiver of the planning provide stage ought to put up the waiver request as a preliminary thought.
Full suggestion target Date(s):
September 08, 2020
December 16, 2020
June 09, 2021
2d Wednesday in June, annually Thereafter
December 08, 2021
2nd Wednesday in December, yearly Thereafter
proposal evaluate guidance standards
benefit overview standards:
national Science Board permitted criteria. extra advantage assessment standards practice. Please see the complete text of this solicitation for additional information.
Award Administration suggestions
additional award situations observe. Please see the total textual content of this solicitation for additional tips.
further reporting necessities apply. Please see the entire text of this solicitation for extra advice.
table OF CONTENTS
abstract of application requirements
thought coaching and Submission instructions
thought education instructions
NSF proposal Processing and evaluation procedures
merit evaluation principles and criteria
assessment and option procedure
Award Administration assistance
Notification of the Award
An IUCRC operates as a consortium integrating trade, govt, and academia. the economic neighborhood includes essential organisations, middle market businesses, small companies and startups; public individuals may range from native governments to divisions of federal businesses. These stakeholders associate to advance vital technologies from early stage analysis to the marketplace (figure 1). The membership fees aid research projects carried out with the aid of institution school and college students. NSF offers funding for operations and a governance framework for membership, operations, and evaluation.
IUCRCs engage in simple research this is considered pre-aggressive. This capability that the research is supposed for e-book through avenues available for educational and scientific research. Pre-competitive analysis permits business contributors who could be competitors within the commercial market to work collaboratively within an IUCRC to support form its research activities and center of attention. IUCRCs are anticipated to work on research it is transformative and helps reshape the frontiers of skills of trade relevance.
An IUCRC gives the infrastructure for practicing a diverse, high-tech personnel, including through the recruitment of students and college of populations traditionally underrepresented in science, technology, engineering, and arithmetic (STEM) disciplines. furthermore, it gives a forum for startups to engage with business and strengthen a prosperous network of corporate, tutorial, and public elements to speed up know-how translation.
determine 1. The IUCRCs role in translating research from conception to commercialization.
II. software DESCRIPTION
An NSF supported trade-tuition Cooperative research middle (IUCRC or core) is a consortium comprising one or greater university sites and a few Member businesses who pay membership fees that aid the middles analysis charges and actions. It carries right here leading facets:
university sites: Universities/associations of larger education (IHEs) taking part in an IUCRC, both as a Lead site or a partner website.
contributors: companies (tremendous and small agencies, startups, for-earnings and non-earnings entities) and govt corporations (federal, state and native) who pay membership charges, diagnosed as software salary (https://www.nsf.gov/publications/pub_summ.jsp?ods_key=pappg); please see section VIII.D.four: application earnings, to become a Member of the IUCRC.
industry Advisory Board (IAB): Representatives from the Member corporations who participate actively in guiding and assisting the IUCRCs mission and vision, research roadmap, and related programs.
NSF: NSF offers funding for administrative expenses, application oversight, and a governance framework to control membership, operations, and assessment.
growing an IUCRC requires a powerful want to build public-private partnerships, skills of pressing trade wants, a equipped management crew, entry to students, and research infrastructure. To launch an IUCRC, the school crew ought to determine the research wants of an financial sector beneath transformation, verify alignment of college leadership, secure monetary commitments from business players, and establish a great governance framework.
NSF considers every IUCRC a nationwide funding and encourages the formation of multi-institution (i.e., multi-web site) facilities, each and every of which should still tackle different, pleasing needs. A potential fundamental Investigator (PI) should verify that a proposed middle does not overlap with current centers within the directory (http://www.iucrc.org/centers); in the adventure of overlap with an current IUCRC, the PI should still discover the chance of joining that middle.
during center creation, NSF money a 12 months-lengthy Planning supply method, throughout the normal NSF advantage evaluate system, to instruct prospective core leaders on best practices for establishing and retaining a a hit IUCRC. The path to center creation (figure 2) involves a few distinctive steps, together with planning, working towards, customer discovery and Member recruitment, and eventually resulting in the submission of a phase I IUCRC idea.
determine 2. The direction to IUCRC introduction from concept to award.
IUCRCs progress from inception through every stage, eventually with the purpose of fitting a Graduated core, which is defined as efficaciously finishing the highest IUCRC phase accessible under the solicitation by which it was funded, continuing to satisfy or exceed the minimum membership and membership fee complete cash requirements, and continuing to use the NSF governance framework. (determine 3). To align with the accelerated tempo and evolution of business analysis, NSF presents new facilities two Phases of funding (five years each). This comprises two funding stage options inside part II (i.e., section II and phase II+).
energetic part I facilities, established beneath this or prior solicitations and transitioning to section II, can be area to the mannequin described in determine 3 (i.e., section II or section II+). lively phase II facilities (funded beneath prior solicitations) might also select to development to section III beneath this solicitation.
figure three: IUCRC evolution and funding paths provided in this solicitation.
core funding model
An IUCRC conducts research beneath the management and tips of an industry Advisory Board (IAB) to manage project preference, fund tasks, and share effects. To qualify for NSF guide, a center should meet certain requirements in each membership and membership prices (see table 1). The core may also offer two membership price degrees (Full and associate). See section B.1 under for definitions of terms and part VII.B for the special Award circumstances.
table 1: IUCRC funding, membership, and price requirements.
Multi-web site core (variety of sites = N)
Annual NSF website Funding2
$one hundred fifty,000
$one hundred fifty,000
Annual minimum Membership (Full memberships or equal)
three x N
four x N
6 x N
5 x N
minimal membership price total3
$150,000 x N
$200,000 x N
$300,000 x N
$250,000 x N
Annual NSF web site Funding
$a hundred and fifty,000
Annual minimal Membership (Full memberships or equal)
minimum membership payment total3
1 part III funding is an purchasable alternative only for energetic section II websites funded below prior solicitations.
2 further flexibility in specifying a centers NSF funds is described in area V.A price range Allocations for middle Operations and administration.
3 doesn’t include in-type contributions.
center constitution and Membership
phrases and Definitions
businesses, Entities, and structure:
web page: a college/institutions of larger learning taking part in an IUCRC.
Lead web page: The website with administrative and administration accountability for the middle-extensive activities corresponding to Member recruitment and retention, IAB meetings organization, assortment and allocation of membership expenses and different program salary, and managing core operations. The Lead web site administrative position and associated charges are described and budgeted in a required Memorandum of figuring out (MOU) finished with the aid of all sites.
partner site: A collaborating web page that is not the Lead web page.
external Collaborator: An exterior entity or individual required to tackle a essential analysis need, discipline to NSF and IAB approval and paid for from program earnings.
industry Advisory Board (IAB): An advisory body composed of representatives from the cores member organizations. The IAB elects a Chair and Vice-Chair and makes concepts on (a) the cores research tasks, (b) the apportionment of resources to those analysis initiatives, and (c) Bylaws. The IAB ensures that the tuition group is conducting research of relevance to the business individuals. The IAB helps to refine the mission, vision, and research roadmap for the core.
educational management crew: A team comprising the PIs and co-PIs of all sites, with accountability for overseeing and undertaking the IAB-counseled research activities and ensuring core success.
backed tasks workplace (SPO) (or equivalent): institution administrative unit on the Lead web page that gives an annual center membership certification kind (https://www.nsf.gov/eng/iip/iucrc/sro.jsp).
academic policy Committee: tuition unit at each and every web site composed of participants of the establishments administration (as an instance, vice chairman of analysis, Dean, affiliate Dean of analysis, Vice Dean of Innovation, department Chair, etc.). Examples of this committees duties encompass managing battle of interest or personnel performance concerns in the core/web page.
section: A part is one in every of two 5-yr sequential degrees of construction and NSF funding. Phases below this solicitation may be I, II or II+, or III. Phases II and II+ don’t seem to be consecutive however rather together unique alternate options for phase II with different NSF funding degrees as a function of the level of trade participation (desk 1). section III is available simplest for active phase II centers funded beneath prior solicitations. A Planning grant does not qualify as a part. A section applies to the entire center; particular person websites cannot be in different Phases in the same middle.
web site addition: facilities may additionally extend to consist of participation from additional institution sites, in order to raise research capabilities and impact. a brand new site may additionally be part of an present core if it might probably display that it could meet NSF membership necessities for the increased middle and its concept have to bear the benefit evaluate system. A web page joins an IUCRC in the centers current phase, with an award limited to the ultimate length of the active middle.
Personnel and Roles:
center Director: The PI of the core Lead web page thought; oversees core operations and administration, core analysis classes and serves because the centers key element of contact.
site Director: The PI for a partner web page; serves on the academic leadership crew, manages the sites analysis program, and serves because the sites element of contact for web page-connected activities.
trade Liaison Officer: This place is typically associated with the Lead site and has the basic tasks for speaking core cost, selecting and recruiting new participants, and building and retaining existing business relationships. This place is incredibly recommended but isn’t required if the middle management has adequate time and experience to perform this extra role. partner websites are expected to deliver partial assist for this place by way of contributing funds as described in section V.A finances Allocations for middle Operations and management for designated suggestions.
costs: The annual monetary commitment, payable in cash (not in-variety contributions), contributed through a Member firm.
Member: price-paying corporation that indications the IUCRC membership settlement.
Full Member: A Member that can pay the entire membership fee, and has one full balloting appropriate.
associate Member: A Member that will pay one-half of the entire Member price, and has one-half of a voting appropriate.
associates: An entity providing authorized in-form contribution, or an entity worried within the middle with battle-of-interest that may additionally wish to help the center with the aid of contributing cash (on the associate membership or full membership stage). associates do not count toward membership expenses, don’t have any vote casting rights and do not have unique or non-unique, royalty-free license access to the middle intellectual Property.
Membership (number of equal Full members): equal Full memberships are counted via aggregating the entire and associate memberships to check compliance with the solicitation requirements (desk 1). as an instance, a center with 4 Full participants and a couple of associate contributors has 5 equivalent Full members.
Membership costs: the whole membership charges amassed. The fees of Full and associate members are aggregated into the membership fee total to assess compliance with the solicitation necessities (table 1).
program earnings: All cash contributed by using contributors are categorised as software salary. at least ninety% of the IUCRC program salary need to be used to support the direct expenses of research, and as much as 10% may well be used to guide oblique costs. For more information, see https://www.nsf.gov/pubs/policydocs/pappg20_1/pappg_8.jsp#VIIID4.
word: The middles industry Advisory Board (IAB) may additionally vote on the allocation of Member funds to assist direct charges aside from research to meet the middles selected wants in support of its mission. The middle may additionally convey selected requests to the IAB for a vote and suggestions.
vote casting rights: balloting rights are assigned in accordance with Membership stage. Full contributors are disbursed one voting correct for one membership charge. A Member may additionally acquire distinctive memberships, however membership contributions in excess of two full memberships are capped at two balloting rights. associate participants pay a decreased (one-half) membership payment, and as a consequence have 0.5 voting rights.
middle research: The middle program profits is directed toward the research activities, as counseled through the IAB, and performed at the sites by using the tuition researchers (faculty, graduate college students, post graduate students, etc.). Membership expenses are classified as program revenue.
Agreements and policies:
Memorandum of understanding (MOU): A Memorandum of understanding (MOU) between sites within the middle ought to be negotiated such that the Lead sites administrative function and associated charges are defined and budgeted. The Lead website serves as a crucial collection and distribution web page for all membership fees and Member-related application salary, including cash allotted to research projects executed at accomplice sites. All sites execute the equal MOU.
NSF budget Allocations: NSF funding for a school web site is supposed to support operations, management, and administration at each the center and placement ranges. web site budgets should allocate NSF cash to the Lead web site for core operations (part V.A).
Bylaws: The core Bylaws outline the operating methods that should be applied to control the operations of the core. These working tactics are accepted by the IAB and the tutorial management group. Bylaws are reviewed via NSF for acceptability with the IUCRC program.
IUCRC Membership contract: All middle contributors sign one regular settlement. The typical template contract to be adopted is posted on the NSF website at https://www.nsf.gov/eng/iip/iucrc/sample_agreement_form.jsp.
Conflicts of pastime: A conflict of interest policy need to be carried out for the middle and presented in the Bylaws, to address groups or entities for which: (1) a researcher involved within the middle is the founder, president, a key officer or a majority shareholder, or (2) the corporation is in any means financially affiliated with any of the colleges which are part of the middle (e.g., university foundation, institution subsidiary).
strategy and Governance
centers are characterised by means of having the following:
A research scope interesting among existing IUCRCs and representing the shared pursuits of the core research team and IAB;
A portfolio of primary and pre-aggressive collaborative research initiatives of pastime to varied IAB members;
A mechanism to share undertaking results with all center contributors;
A plan for attracting new contributors, holding present members, and constructing potent relationships between the middle research crew and IAB;
A plan to set up a various mix of trade Member groups, including corporations (big and small), startups, non-earnings businesses, executive corporations, and/or different involved non-academic entities;
amazing representation via all websites in middle analysis activities, with an emphasis on tasks requiring engagement and collaboration among dissimilar sites;
A precedence-driven ranking mechanism by which the IAB can suggest funding. (A balloting system that permits one IAB Member to independently fully fund its undertaking(s) of option is considered as assisting contract work and is disallowed under the IUCRC framework);
Documentation of center goals and targets, created jointly by the core analysis group and the IAB, and an linked analysis roadmap;
A uniform membership settlement conforming to the NSF IUCRC-large model (https://www.nsf.gov/eng/iip/iucrc/sample_agreement_form.jsp );
A Memorandum of knowing articulating the financial and operational responsibilities of every web page;
a collection of IAB-accepted core Bylaws to document middle working methods, in step with the IUCRC membership contract and model, together with a method to reorganize leadership at the core or web page level if deemed crucial by the NSF and IAB.
Eligibility for Membership
members are vital to effective center functioning, as they vote to advocate initiatives of mutual hobby with a purpose to kind the analysis portfolio. additionally, they define which initiatives are chosen, fund analysis, and display screen center efficiency.
individuals may be agencies (big and small), startups, non-income companies, government organizations, and/or other interested non-tutorial entities. To make certain research translation into commercial makes use of for societal have an impact on, NSF encourages centers to recruit IAB individuals primarily from the deepest sector. the following eligibility necessities observe:
participants need to have an organisation Identification number (EIN) issued by means of the U.S. interior income service. Exceptions to this requirement have to be approved in writing by using the cognizant program Officer.
Two divisions inside the identical father or mother firm count as diverse members simplest if every division has a unique EIN.
An entity ought to submit a signed IUCRC membership contract (See Agreements and policies section II.B.1) to the Lead website SRO and pay an annual membership charge.
U.S. federal businesses, Federally Funded research and construction centers (FFRDCs), country wide laboratories, and state and native govt agencies may also turn into contributors (https://www.nsf.gov/eng/iip/iucrc/govt.jsp). different entities inside a government company qualify as distinctive participants (e.g., military CERDEC and armed forces analysis Laboratory).
An entity financially linked with any of the websites (e.g., a school groundwork or subsidiary) may additionally become an Affiliate Member of that middle. The entity’s membership fee counts as software income. The entity and its membership expenses don’t count towards core minimum membership requirements. The entity doesn’t have IAB balloting rights. Any center-supported school concerned in an Affiliate Member business must supply written be aware to the core Director and the center IAB of their involvement in the company and need to agree to battle of interest policies of their institution.
An entity or business through which a center college member is the founder, president, key officer, or predominant shareholder, may additionally develop into an Affiliate Member of the middle. The entity’s membership charge counts as application salary. The entity and its membership costs don’t count number towards core minimal requirements. The entity does not have IAB balloting rights.
classes and memberships: a middle may have three membership classes: Full, associate, and Affiliate. Full participants pay 100% of the fee, associates pay 50% of the price, and Affiliate members may additionally provide in-type contributions or pay prices that count as program profits however that do not count towards assembly membership payment necessities (table 1). The distinctive variety of affiliate members will also be delivered collectively to create an equivalent Full Membership (e.g., two associate members at 50% are similar to one Full membership).
voting rights: A full Member earns one vote. vote casting is professional-rated in accordance with the paid membership charge. a company may additionally purchase numerous memberships in a middle, but contributions exceeding two full memberships are capped at two votes. Affiliate members should not have voting rights.
In-kind contributions: An in-type contribution by means of an Affiliate Member, reminiscent of (however now not limited to) gadget or devices, should be authorized by way of IAB and doesn’t qualify towards assembly minimum membership price total cash contribution requirements set by NSF.
illustration: as an instance, in desk 2 a part I middle is proven that has two websites providing full and associate memberships with price ranges of $50,000/$25,000 respectively, in addition to affiliate memberships. This middle have to have as a minimum 6 full memberships (three x 2 websites) and $300,000 ($a hundred and fifty,000 x 2 sites) in total membership prices cash contributions all the way through every year of part I. The middle has $625,000 of software earnings, 9.5 vote casting rights, 7 full memberships, and $525,000 in eligible membership costs.
table 2: illustration calculation for assembly membership and payment requirements.
program earnings from Membership fee
vote casting Rights
Membership (number of equivalent full members)
Cap of 2 votes for any Member
In-type doesn’t count number towards membership
PI-linked startup H
PI is conflicted
school-affiliated non-income J
web page is conflicted
government agency ok
core stages and Evolution
each and every proposed site seeks funding from NSF for formal planning actions in a preliminary suggestion in short describing the center idea, every websites role, and the prospective groups and government organizations interested in the center. After assessment, NSF encourages or discourages submission of a full inspiration for a Planning supply. IUCRC Planning Grantees are required to participate in right here activities: 1) a Boot Camp to learn how to create a sustainable middle; and a couple of) a two-day Planning Workshop geared up by means of the Grantees, enticing abilities IAB participants in a dialogue of the proposed middle focus, its cost propositions, competencies research initiatives, and a analysis roadmap of strongest activity to industry participants.
Planning furnish Boot Camp
NSF oversees and runs the Boot Camp to train a superior planning technique, including Member discovery and recruitment, as well as most useful practices in middle operations. Attendance is obligatory. Key members include the Lead web page PI (i.e., center Director), the PIs of accomplice website awards (site directors), the center business Liaison Officer (if identified), and different key center team individuals.
A Planning furnish dollars a two-day workshop for middle college to have interaction potential agencies and government organizations (i.e., potential participants) to focus on the IUCRC model, proposed center of attention, and price proposition. Workshop consequences encompass: 1) A analysis roadmap and a portfolio of proposed ingenious initiatives addressing giant trade challenges; 2) A sufficient number of fiscal commitments from prospective contributors to satisfy or exceed phase I membership and membership fee total requirements; and three) A group of school, staff, and institution administrators committed to main a transformative analysis software.
a potential IUCRC consortium that has already completed planning activities and completed the Planning grant Workshop consequences outlined above might also are looking for a Planning supply waiver (field to NSF approval) to accelerate core formation and bypass the NSF-funded Planning grant stage.
for new IUCRCs created and funded under this solicitation, NSF provides help to facilities/websites for a five-year phase I award. The phase I award is required to follow for section II.
A section II grant enables a center to develop and diversify its membership and analysis portfolio. within the remaining year of phase I, all of the sites practice as a group for part II (years 6-10 of the core). The middle should reveal that it met NSF supply necessities throughout phase I and might meet the minimum part II membership and funding dedication necessities.
part II has two together-exclusive funding designations part II and phase II-Plus (part II+). The alternative of section II or section II+ must be decided on the time of thought submission. Transitions from section II to phase II+ and vice versa in the phase II award period is illegal.
phase II is for an N-site center that seeks to preserve an annual minimal equivalent full membership level of four individuals x N and annual minimal membership fees of $200,000 x N. The middle may additionally request an NSF finances of $a hundred,000 per web page per year. Single web page part II facilities must have an annual minimum equal full membership degree of 8 individuals, annual minimal membership fees of $400,000 and may request an NSF price range of $a hundred,000 per yr.
part II+ is for an N-site center that seeks to retain an annual minimum equivalent full membership degree of 6 individuals x N and annual minimum membership charges of $300,000 x N. The middle may additionally request an NSF price range of $one hundred fifty,000 per web page per year. Single site phase II+ centers need to have an annual minimum equivalent full membership level of 12 contributors, annual minimum membership charges of $600,000, and can request an NSF funds of $a hundred and fifty,000 per 12 months.
be aware: section I IUCRCs planning to post a section II+ should achieve a considerable ramp up of membership during part I to be in position to meet the bigger membership necessities of the phase II+. as an instance, N-web page section I facilities should still are seeking to reach 5XN memberships through year 5 to be in a far better position to meet or exceed the membership requirements of the part II+.
section III (restrained availability)
lively part II centers presently funded below prior IUCRC software solicitations may compete for an extra five years of part III funding. See table 1 for further particulars and requirements.
part III is obtainable simplest to lively section II centers funded beneath prior solicitations and might remaining 5 years. a middle should be within the ultimate year of phase II as per the solicitation under which it turned into funded. A web page that has been introduced in phase II below this solicitation, to an existing center (that has websites funded below prior solicitations), could be accepted to follow for part III if the middle chooses to transition to phase III as allowed during this solicitation.
A section III, part II, or section II+ core funded under this solicitation is anticipated to attain self-sustainability on the end of the award duration.
Addition of a web page to an existing middle
A site joining an latest NSF-funded core will post a full proposal to NSF to be a part of the present section of the middle and is proscribed to the centers remaining duration. for instance, if a center is in 12 months two of phase II, the site may additionally most effective practice to be part of that middle as a phase II site (now not part I, in spite of the fact that it’s that web pages first yr) for the closing 3 years of part II. the brand new web page should make contributions to the requisite new Member number and incremental monetary commitment to help the requirements (table 1), as modified to mirror the brand new website addition; evidence of this means have to be presented with the brand new websites Full inspiration. a brand new sites price range request is restricted per table 1.
instance: A two-website phase I middle with a $50,000 membership payment and seven qualifying memberships summing to a membership fee complete of $350,000. The core exceeds the mandatory member number and charges (i.e., 6 contributors and $300,000 in charges; see table 1). youngsters, if the middle adds a new web site, the core ought to display 9 memberships and costs summing to $450,000. the brand new site thought have to hence coordinate with the Lead web page/center Director to establish and include fiscal commitment letters from as a minimum 2 new members proposing an extra $one hundred,000 or greater.
the new website ought to execute the equal MOU because the centers other sites, to make a contribution to funding the Lead websites administrative expenses.
a middle may continue to appear within the lively IUCRC portfolio as a Graduated center if it successfully completed the highest IUCRC section accessible below the solicitation through which it become funded, continues to fulfill or exceed the NSF requirements of that section as detailed in that solicitation, and continues to use the NSF governance framework. To be registered as a Graduated core, the middle Director need to put up a document annually to NSF by way of electronic mail to IUCRC@nsf.gov for evaluate.
Supplemental funding opportunities
lively supplemental funding opportunities are described in stronger element right here: https://www.nsf.gov/eng/iip/iucrc/funding.jsp
All requests should be discussed with the cognizant program Officer and accredited just before submission as no longer all NSF Directorates support all supplement kinds.
supplements to boost IUCRC training and schooling
a center might also develop its practicing and training mission via numerous supplemental funding alternatives (restrained to the availability of funds and different programmatic considerations). obtainable dietary supplements consist of:
Non-academic analysis Internships for Graduate students (INTERN): aid graduate college students in research in non-educational settings, including enterprise and executive laboratories, to boost student profession advantage and provide work journey outside of academia; usually, up to $55,000
research journey for Undergraduates (REU): support undergraduate pupil involvement in analysis; usually, as much as $eight,000 per scholar
analysis Experiences for academics (RET): support research participation by means of ok-12 lecturers and neighborhood college instructors; usually, up to $10,000 per teacher
Veterans analysis complement (VRS): help analysis participation by undergraduate or graduate students, k-12 STEM academics, or group school instructors and students who have served in active responsibility with the U.S. armed forces; usually, as much as $10,000 per veteran
international dietary supplements
Collaboration with leading foreign analysis entities can extra strengthen a middles desires. With prior approval of the IAB and NSF, a middle may submit a supplemental funding request to foster collaborative work with a global companion; the inspiration should encompass particulars on:
Description of how the IUCRC would have interaction with the international research site;
Description of the proposed research tasks;
Description of the latest infrastructure to allow collaboration;
facts that the overseas research entity has ample business partner funding to assist the proposed tasks, at a degree of analysis activity comparable to what’s ongoing at the U.S. IUCRCs sites;
Documentation that the international website has been/will be based following the framework of the IUCRC governance mannequin;
A memorandum of understanding (MOU) between the NSF IUCRC and the foreign web site addressing IP rights, copyrights, book delays, and participation of the international site business members within the IUCRC business Advisory Board activities; and
A letter from the IUCRC IAB endorsing the overseas collaboration and the above mentioned MOU.
For IUCRCs with international collaborations, NSF will accept as true with: intellectual merit of the collaboration with the international companion(s), advantages to be realized from the overseas companion’s potential and really expert talents, amenities, websites, and/or components of the international counterpart, and lively research engagement of IUCRC-based students and early-profession researchers, as acceptable.
This collaboration and its funding are energetic throughout the section by which the foreign complement request changed into accredited. each and every IUCRC is limited to at least one annual foreign complement request, no longer to exceed $25,000. money are to be used handiest for costs involving the foreign exercise, corresponding to research visits by using center school and students to the foreign site for research and collaborative actions. NSF money may now not be used by way of foreign companions.
III. AWARD advice
expected classification of Award: general provide or continuing provide
Estimated variety of Awards: 10
2 to 8 full core awards and four to 6 Planning furnish awards annually.
predicted Funding amount: $20,500,000
individual award sizes (complete charges):
$20,000 for Planning provides
$150,000 per 12 months for phase I
$one hundred,000 per year for part II
$one hundred fifty,000 per yr for part II+
$50,000 per 12 months for phase III
Planning offers are supposed to be awarded as common supplies. All center website grants may be awarded as continuing supplies.
Estimated application budget, variety of awards and regular award dimension/duration are discipline to the provision of money.
IV. ELIGIBILITY tips
Who may put up Proposals:
Proposals may additionally only be submitted by way of the following:
associations of better schooling (IHEs) – Two- and four-12 months IHEs (together with neighborhood schools) authorised in, and having a campus determined within the US, appearing
on behalf of their school members. particular guidance for international department Campuses of US IHEs: If the inspiration comprises funding to be offered to an
overseas branch campus of a US institution of greater education (together with via use of subawards and advisor arrangements), the proposer need to explain
the improvement(s) to the task of performance on the overseas department campus, and justify why the project actions cannot be carried out at the US campus.
Who may serve as PI:
The important Investigator (PI) on a proposal have to be a tenured school member. Requests for waivers to permit non-tenured school or analysis staff to serve as PI need to be submitted in writing to the cognizant program Officer by way of the PI’s supervisor (e.g., department Chair or Dean) in advance of notion submission. further, written approval from the cognizant software Director is required previous to idea submission and will be blanketed as a Single reproduction document within the idea. The PI must act as the initial website Director. A PI/Co-PI can have just one energetic IUCRC web site award at any given time.
limit on variety of Proposals per company:
There is no limit to the variety of proposals an eligible firm may additionally publish to this application as long as each and every concept pertains to a different IUCRC.
limit on number of Proposals per PI or Co-PI:
PIs and Co-PIs can most effective put up one concept per submission period. A PI/Co-PI can have just one lively IUCRC web page award at any given time.
further Eligibility data:
Preliminary proposals are required earlier than submission of planning offers. Submitters looking for a waiver of the planning furnish stage, need to post the waiver request as a preliminary idea.
Planning provide. A PI should put up a preliminary suggestion to be eligible to put up a Planning furnish Full notion.
part I idea. Consortia who have correctly completed the Planning provide manner (including the Boot Camp practicing and Planning Workshop) are eligible; then again, consortia who have bought an NSF-accepted Planning grant waiver are additionally eligible.
part II or phase II+ proposals. energetic section I facilities are eligible.
section III proposals. energetic phase II facilities funded below prior solicitations are eligible.
A idea reviewed below this solicitation or below NSF 17-516 that was up to now declined, can be revised and resubmitted for additional consideration in accordance with the requirements of this Solicitation.
V. proposal practise AND SUBMISSION guidelines
A. concept training directions
Preliminary Proposals (required): Preliminary proposals are required and have to be submitted by means of the NSF FastLane gadget, notwithstanding full proposals may be submitted by way of supplies.gov.
Preliminary proposals are required previous to submission of planning gives you. Submitters in the hunt for a waiver of the planning furnish stage should publish the waiver request as a preliminary inspiration. page limits detailed listed here are maximum. each establishment should submit its personal Preliminary proposal.
This solicitation carries the assistance vital to prepare a idea and refers to certain sections of the PAPPG best when necessary. The instructions in this solicitation take priority over guidance within the PAPPG within the experience of deviations.
Planning supply Preliminary suggestion Title
challenge Title format: IUCRC Preliminary concept [Planning Grant, Planning Grant Waiver request] [Site Name]: core for [Center name] [Center Acronym]
Designations inner the first set of rectangular brackets indicate the category of notion submitted (Planning furnish or Planning supply Waiver request). [Site Name] is the identify of the submitting establishment. The core name should still in brief describe the middle’s research center of attention, which may still be followed by means of an acronym (e.g., "IUCRC Preliminary inspiration Planning furnish crimson River tuition: core for Cloud Computing and Innovation (CCI)”).
Award dimension and period requested:
Planning provide: up to $20,000 for 365 days.
Planning grant Waiver: as much as $750,000 for 60 months for a web page in a section I middle.
Biographical counsel for Preliminary Proposals (2 pages)
give one paragraph in prose for every member of the analysis crew for the whole middle.
mission Description for Preliminary Proposals (2 pages)
birth with the challenge title and kind (e.g. Planning furnish or Planning supply Waiver request). focus on:
The proposed center’s imaginative and prescient and mission;
Key unmet business analysis wants riding center creation;
financial significance of the research enviornment;
Demonstration of middle’s specialty and differentiation from different IUCRCs and NSF-funded facilities;
Pre-current research partnerships between the websites concerning the center’s focal point;
list of skills research thrust areas and deliberate collaborative, synergistic, and center-huge contributions with the aid of the web page;
record of potential individuals, commentary of who has already been contacted, and the estimated level of pastime; and
For each and every site consist of specific tips involving its school, capabilities, and elements to be contributed to the middle.
Supplementary Documentation for Planning provide Waiver Requests simplest (three pages)
Describe the imperative middle/web site planning activities/workshops/activities involving lively trade engagement up to now. listing every organization committing to be part of the core and specify the volume and duration of its annual fiscal dedication.
selections on Planning supply Preliminary Proposals and Planning grant Waiver Requests
Submitting PIs of a Preliminary inspiration will acquire an inspire or Discourage decision from NSF. NSF’s encourage/Discourage choice made on the preliminary concept or a planning supply waiver is advisory only. This capacity that PIs of each favorably and unfavorably reviewed Preliminary Proposals are eligible to put up full proposals.
An encourage discovering shows that the thought looks to be aware of this solicitation and is a candidate for full inspiration benefit overview. A discourage discovering suggests that the task did not reply to the solicitation and has a low probability of funding guide. Full inspiration preparation instructions: Proposers may opt to put up proposals in line with this software Solicitation by means of FastLane or offers.gov.
Full proposals submitted via FastLane: Proposals submitted in line with this software solicitation may still be prepared and submitted in accordance with the widespread guidelines contained within the NSF notion & Award guidelines & tactics book (PAPPG). The comprehensive textual content of the PAPPG is accessible electronically on the NSF web site at: https://www.nsf.gov/publications/pub_summ.jsp?ods_key=pappg. Paper copies of the PAPPG can be acquired from the NSF Publications Clearinghouse, cellphone (703) 292-8134 or via e-mail from firstname.lastname@example.org. Proposers are reminded to establish this application solicitation number within the application solicitation block on the NSF cover Sheet For suggestion to the countrywide Science groundwork. Compliance with this requirement is important to identifying the vital idea processing instructions. Failure to post this advice may additionally prolong processing.
Full proposals submitted by means of promises.gov: Proposals submitted in line with this program solicitation by the use of delivers.gov should still be prepared and submitted in line with the NSF grants.gov software e-book: A book for the training and Submission of NSF functions by means of delivers.gov. The finished textual content of the NSF delivers.gov utility ebook is accessible on the supplies.gov web page and on the NSF website at: (https://www.nsf.gov/publications/pub_summ.jsp?ods_key=grantsgovguide). To acquire copies of the application guide and utility varieties kit, click on the observe tab on the delivers.gov website, then click on on the observe Step 1: down load a provide application equipment and application guidance hyperlink and enter the funding probability quantity, (the software solicitation quantity without the NSF prefix) and press the down load equipment button. Paper copies of the can provide.gov application guide additionally can be got from the NSF Publications Clearinghouse, telephone (703) 292-8134 or by using e mail from email@example.com.
See PAPPG Chapter II.C.2 for assistance on the required sections of a full analysis suggestion submitted to NSF. Please note that the thought education instructions offered during this program solicitation may additionally deviate from the PAPPG instructions.
Full proposals are required for Planning supplies, web site Additions, and all Phases (section I, II, II+, and III) to this solicitation. each and every website ought to publish its own particular person full notion for any IUCRC proposals.
challenge Title layout: IUCRC [Planning Grant, Phase I, Phase II, Phase II+, Phase III] [Site Name]: middle for [Center name] [Center Acronym].
Designations inside the first set of square brackets point out the type of notion being submitted, and just one of the options therein should be selected. [Site Name] is the identify of the submitting establishment. The core name should still in short describe the middle’s analysis focal point, which should still be followed via the center acronym (e.g., "IUCRC phase II+ red River school: core for Cloud Computing and Innovation (CCI)”).
Planning provide: 365 days.
Phases I, II, II+, and III: 60 months.
web page addition: core’s final provide duration in its existing part.
observe guidance in the PAPPG.
table of Contents
comply with directions within the PAPPG.
project Description (20 pages optimum)
the primary 5 to 10 pages are for “core concentrated content material,” and should be similar for each and every web site among a multi-website center proposal. The closing 10 to 15 pages are “website-specific content material” selecting specific contributions, capabilities, and distinctiveness at each web site.
the first 5 to 10 pages of the “middle concentrated content material” include:
Overview: State the mission and vision; country wide strategic magnitude and uniqueness; unmet/underserved pre-aggressive research has to be addressed.
Broader impacts: focus on the projected societal have an impact on of the center’s analysis, training, and outreach activities.
core Composition: identify the Lead web page and partner websites. How do each website’s capabilities contribute to understand the core’s mission and vision?
management team: focus on the historical past, skills, and management event and capabilities of the important thing group participants (one prose paragraph per group member).
business partners: talk about financially committed and potential (uncommitted) contributors when you consider that joining the core, and your proposed membership scheme and pricing constitution (i.e., Full/affiliate contributors, and many others.).
external Collaborators (analysis contractors): If relevant, describe any external collaborators projected to aid with the center’s success. don’t include IAB contributors, web page personnel, or others engaged with the core as university school, staff, or college students.
trade Engagement Plan: focus on plans for consumer discovery and business recruitment and retention to have interaction a imperative and diverse mix of industry contributors, including groups (tremendous and small), startups, non-income groups, government agencies, and/or other fascinated non-educational entities. talk about the plans to actively interact business participants in ongoing center actions.
Outreach and communication: discuss the communications method to attain prospective individuals, educational companions and the widely wide-spread public. talk about efforts to develop industry participation in the middle.
Operations: talk about the administration plan, organizational structure, operational techniques, financial statement, and risk administration linked to the center.
Sustainability Plan. Describe the middle’s method for turning out to be and reaching self-sustainability by the point of commencement (i.e., 10 years for the brand new mannequin described in this solicitation, or the remaining years for lively section II facilities funded under prior solicitations).
outcomes from Prior core Accomplishments: For part II, II+ and phase III proposals, deliver a quick description of core successes and accomplishments in keeping with the prior phase of operation, with selected focal point on research effects (i.e., improvements that have transitioned to industrial observe), tutorial consequences (college students positioned in industrial positions or conducting industrially-relevant analysis as school participants), educational consequences (postdoctoral fellows, team of workers, and college who have earned attention for high-quality research), and the financial and membership fitness of the core during the prior NSF funded part.
in a similar fashion, for phase I proposals, provide results from the Planning grant manner.
The last 10 to 15 pages of the “web site-certain content material” should still be enjoyable to each and every partner site and consist of:
Planning furnish proposals: listing up to 5 prospective analysis initiatives per web page to be proposed to potential IAB participants at the middle Planning Workshop.
Phases I, II, II+, III: discuss the expected research initiatives and each site’s function, including: 1) leap forward abilities, innovative ideas, and cost propositions; 2) the diploma of collaboration and interdisciplinarity (go-departmental, college and institution); 3) the broader societal and business have an effect on of the analysis; and 4) any enjoyable capabilities and contributions of the website.
website addition: Describe certain tasks to be undertaken at the website and clarify how this augments the center’s analysis roadmap and existing capabilities.
personnel development Plan. discuss how the certain web site will make a contribution to working towards, internships and mentoring students of all degrees, making ready them for future career paths to boost the countrywide body of workers.
The PAPPG requirement to consist of effects from Prior NSF help within the challenge Description is waived. This information is now supplied as Supplementary document H.
observe guidelines in the PAPPG.
comply with guidance within the PAPPG.
funds and price range Justification
Planning grants: money may well be used for travel through core/web site crew members (e.g., submit-docs, students, other elementary personnel) to the Boot Camp and Planning Workshop, price for the planning meeting room and/or AV condominium, practise of assembly materials, middle communications, consultants to create cost from the planning activities, visits and engagement with potential Member organizations and attendance, and school time. NSF cash may no longer be used for IAB shuttle or prices.
Phases, I, II, II+, III, and placement Additions: NSF dollars should be used towards administration and operations of the IUCRC, comparable to: faculty time, trade Liaison Officer time, experience and travel prices of IAB meetings, center communications, publications of center research, and travel regarding Member recruitment. enhance approval by means of the cognizant application Director is required to make use of NSF money for research. In multi-web page centers, administrative and operational fees should be addressed as follows:
price range Allocations for center Operations and management:
NSF funding for a university web page is meant to aid operations, administration, and administration at each the middle and site levels. website budgets ought to allocate NSF money to the Lead web site for middle operations via certainly one of two informed approaches:
Unequal NSF budgets: For a given NSF complete middle budget, partner websites might also agree with requesting a smaller NSF finances request than the allowed maximum, permitting the Lead site to request a larger NSF price range amount to cover the core operation, management, and administrative charges.
For an N-web site center, the total core price range for phase I should be $one hundred fifty,000 x N; for phase II it can be $a hundred,000 x N; and for section II+ it will be $150,000 x N.
Equal NSF budgets: All websites may request the same allowed highest NSF finances, but the partner websites are expected to budget for switch of middle operations funds to the Lead site via subawards. just before submission of the IUCRC proposals, the tuition sites may still execute and publish an MOU that establishes agreed upon oblique charge rates and procedures for managing such transfers.
As part of the of the center Description, the proposals ought to naturally specify the financial plan to make a contribution in opposition t covering the charges of core operations on the Lead web page.
present and Pending guide
follow guidance in the PAPPG.
facilities, device and elements
observe guidance in the PAPPG.
Supplementary files consist of these required files in the "Supplementary documents" element of FastLane (ForGrants.gov clients, supplementary files should still be attached in field 12 of the R&R other Attachments.). primary Investigators should still confer with table 3.
notice: Single-site facilities need to put up all supplementary documents listed in desk 3, with the only real exceptions of Supplementary doc D (Memorandum of realizing) and i (Joint Letter of support).
desk three. summary record of Supplementary documents
Phases requiring this doc
website in a multi-website middle that must submit this document
Letters of activity
2 pages per letter
Lead web site best (Lead web site materials these for site addition proposals)
Letters of economic commitment
2 pages per letter
Phases I, II, II+, III, website Addition
Lead website most effective (Lead site supplies these for website addition proposals)
All phase II, II+, III, and placement Addition
Lead website best for phase II, II+, and III (Lead website resources these for web site addition proposals)
Memorandum of knowing
Phases I, II, II+, III, web site Addition
Lead web page most effective (Lead website resources these for website addition proposals)
Documentation of center area of expertise among IUCRCs
Planning supply and section I
Lead web site best
records administration Plan
Lead and associate sites
Postdoctoral Mentoring Plan
All (if appropriate)
Lead and companion websites
results of Prior NSF support
Lead and accomplice sites
Joint Letter of assist
2 pages per letter
web page Addition
web page in quest of addition
clarification of Supplementary documents:
Letters of pastime (simplest for Planning can provide and only protected in the Lead site inspiration). For web page Addition, Lead web site/center Director offers the letters to be covered with the notion.
as a result of a middle in the planning stage does not yet have dedicated participants, this supplementary document incorporates Letters of pastime from at least nine (9) advantage members times the number of sites in a multi-web site center (e.g., a three-web page middle would need at the very least 27 letters). A single-website core wants at least 24 Letters of activity. In a Letter of pastime, an interested celebration may still state how and why the company may also support the center’s idea and proposed analysis agenda, as neatly because the importance of the proposed middle to the fascinated party.
Letters of financial dedication (For part I, II, II+, III, and placement Addition; handiest covered in the Lead web page suggestion). For web site Addition, Lead website/middle Director gives the letters to be included with the suggestion.
This package includes the proposed preliminary IAB, with tips on each Member’s eligibility and membership price contribution. each proposed Member should deliver a letter with the following language:
should still core name be selected by using NSF for funding, company name commits to becoming a member of middle identify as a Full/ affiliate Member on the membership level of $quantity on an annual foundation, pending availability of dollars, and accepting the NSF’s required Membership agreement.
Membership Certification (For part II, II+, III, and site Addition). For web site Addition, Lead web page/core Director provides the certificates(s) to be protected with the thought.
For section II, II+, and III proposals, the Lead site ought to include all the valuable prior part official membership certifications, signed by using the authorized Organizational consultant (AOR) of the subsidized research workplace (SRO) of the middle Lead or companion websites. for example, if the center’s prior part I operated beneath a centralized funds collection model, the Lead web site of the phase II concept should attach the section I center’s membership certification. even so, if the prior section I center operated under a web site primarily based cash collection mannequin, the Lead web page’s phase II suggestion should latest all prior legit membership certificates from partner websites, add the prior Lead website membership certification, and include the package as Supplementary doc C within the idea. This gives proof of the eligible membership fee contributions and number of eligible different individuals for the core’s prior part. This guidance can be used to investigate that the center’s prior section has met or surpassed IUCRC membership necessities.
For site Addition proposals, the PI have to work with the present core Director to collect and encompass as Supplementary doc C, all of the current center’s pertinent authentic membership certification(s). This gives evidence of the eligible Membership payment contributions and variety of eligible distinctive members of the latest center. This assistance, mixed with the brand new financial commitments of potential members may be used to investigate that the core will nevertheless meet IUCRC necessities if the new website is delivered.
Memorandum of knowing (MOU) among core’s sites (typical to all websites; Phases I, II, II+, III, website Addition). best blanketed in the Lead site proposal. For web page Addition, Lead website/center Director provides the MOU to be included in the web page addition proposal.
Describe how websites plan to operate the center, share administrative and managerial tasks, tackle the assortment and certification of membership prices, and the funding allocation in line with core’s chosen analysis initiatives, The MOU(s) must be signed. For a website Addition, the MOU ought to be finished.
Documentation of center area of expertise among IUCRCs (Planning offers and phase I)
This justification is required for proposals where NSF has expressed challenge about feasible overlap in its response to the preliminary notion. This letter is authored with the aid of the middle Director of an current IUCRC if NSF has indicated subject about overlap. New IUCRCs need to reveal restricted to no overlap in analysis foci with an present IUCRC.
statistics management Plan (core-large and per web page as relevant)
observe directions within the PAPPG.
Postdoctoral Mentoring Plan (web page-selected)
follow directions in the PAPPG.
results from Prior NSF support (website-particular)
This doc is required for all full proposals, however the content varies with concept stage, as follows. each website have to put up its personal results from Prior NSF help for its personal website PIs.
Planning supply– focus on work performed with prior or existing NSF funding, specializing in the research enviornment of pastime to the middle or synergistic training and training actions.
section I – Describe the involvement of abilities IAB participants within the Planning Workshop, the assignment selection technique, the ensuing proposed research tasks, and the particular position of each and every website. If NSF waived the Planning provide requirement, describe core planning movements, workshops, and activities actively engaging business and the way that process aligned core objectives with prospective Member wants. focus on how analysis projects were selected.
section II, II+ or III – Describe the consequences and affects of center research and membership increase. each and every web page should still talk about its certain position within the core’s activities and successes.
Joint Letter of guide from the Director and IAB Chair of the latest middle (site Addition simplest)
This letter should still clearly articulate the value of the brand new web site to the current core, describing the core’s vetting.
B. Budgetary counsel
Inclusion of voluntary committed can charge sharing is prohibited.
oblique can charge (F&A) boundaries:
Membership costs obtained through the core are regarded software earnings. at the least ninety% of the IUCRC program earnings must be used to help direct costs of the analysis, and as much as 10% may well be used to aid oblique expenses.
NSF award cash are discipline to an institution’s federally-negotiated indirect cost fee. See special Award circumstances.
different Budgetary barriers:
Please check with solicitation textual content.
funds instruction guidelines:
Please consult with solicitation textual content.
C. Due Dates
Preliminary suggestion Due Date(s) (required) (due through 5 p.m. submitter’s native time):
July 07, 2020
September 16, 2020
March 10, 2021
2d Wednesday in March, annually Thereafter
September 08, 2021
2nd Wednesday in September, annually Thereafter
Preliminary proposals are required previous to submission of planning grants. Submitters searching for a waiver of the planning provide stage should post the waiver request as a preliminary thought.
Full idea target Date(s):
September 08, 2020
December 16, 2020
June 09, 2021
2nd Wednesday in June, yearly Thereafter
December 08, 2021
2nd Wednesday in December, yearly Thereafter
D. FastLane/analysis.gov/grants.gov necessities
For Proposals Submitted by the use of FastLane or research.gov:
To prepare and publish a proposal by means of FastLane, see specified technical guidelines accessible at: https://www.fastlane.nsf.gov/a1/newstan.htm. To prepare and put up a idea by means of research.gov, see unique technical directions available at: https://www.analysis.gov/research-portal/appmanager/base/desktop?_nfpb=actual&_pageLabel=research_node_display&_nodePath=/researchGov/carrier/desktop/ProposalPreparationandSubmission.html. For FastLane or research.gov consumer aid, call the FastLane and analysis.gov help Desk at 1-800-673-6188 or email firstname.lastname@example.org or email@example.com. The FastLane and research.gov help Desk answers universal technical questions regarding using the FastLane and research.gov programs. certain questions related to this software solicitation should be referred to the NSF program body of workers contact(s) listed in area VIII of this funding possibility.
For Proposals Submitted by means of offers.gov:
before the use of gives you.gov for the first time, each and every corporation need to register to create an institutional profile. as soon as registered, the applicant’s organization can then observe for any federal provide on the promises.gov web page. comprehensive counsel about using delivers.gov is attainable on the can provide.gov Applicant supplies webpage: https://www.can provide.gov/web/gives you/applicants.html. moreover, the NSF delivers.gov application book (see hyperlink in area V.A) provides guidance concerning the technical training of proposals by way of can provide.gov. For supplies.gov consumer aid, contact the can provide.gov Contact core at 1-800-518-4726 or with the aid of e-mail: aid@can provide.gov. The supplies.gov Contact center solutions established technical questions concerning using delivers.gov. certain questions concerning this application solicitation should still be referred to the NSF software personnel contact(s) listed in part VIII of this solicitation.
Submitting the notion: as soon as all documents had been accomplished, the licensed Organizational representative (AOR) should put up the utility to provides.gov and investigate the desired funding probability and company to which the application is submitted. The AOR must then signal and put up the utility to supplies.gov. The achieved software might be transferred to the NSF FastLane system for further processing.
Proposers that submitted by the use of FastLane or research.gov may use analysis.gov to examine the popularity of their submission to NSF. For proposers that submitted by means of gives you.gov, except an application has been bought and validated by NSF, the licensed Organizational representative may additionally investigate the repute of an application on delivers.gov. After proposers have got an e mail notification from NSF, analysis.gov should still be used to investigate the fame of an utility.
VI. NSF suggestion PROCESSING AND evaluate procedures
Proposals received through NSF are assigned to the applicable NSF application for acknowledgement and, if they meet NSF necessities, for review. All proposals are carefully reviewed through a scientist, engineer, or educator serving as an NSF application Officer, and usually by three to ten other humans backyard NSF either as ad hoc reviewers, panelists, or both, who’re consultants in the selected fields represented via the idea. These reviewers are chosen by using software Officers charged with oversight of the evaluate method. Proposers are invited to suggest names of individuals they agree with are specially neatly qualified to assessment the proposal and/or humans they might select not overview the idea. These suggestions may also serve as one supply within the reviewer option method on the software Officer’s discretion. Submission of such names, however, is optional. Care is taken to make certain that reviewers haven’t any conflicts of interest with the suggestion. in addition, software Officers may also obtain feedback from website visits earlier than recommending last action on proposals. Senior NSF team of workers additional evaluate suggestions for awards. A flowchart that depicts the entire NSF thought and award technique (and linked timeline) is blanketed in PAPPG demonstrate III-1.
A finished description of the groundwork’s advantage evaluate technique is obtainable on the NSF web site at: https://www.nsf.gov/bfa/dias/policy/merit_review/.
Proposers may still also be aware of core suggestions which are simple to the achievement of NSF’s mission, as articulated in constructing the longer term: Investing in Discovery and Innovation – NSF Strategic Plan for Fiscal Years (FY) 2018 – 2022. These techniques are integrated in the program planning and implementation system, of which inspiration evaluation is one half. NSF’s mission is in particular neatly-implemented through the integration of research and education and broadening participation in NSF classes, projects, and actions.
some of the strategic pursuits in help of NSF’s mission is to foster integration of analysis and schooling throughout the programs, tasks, and actions it supports at academic and research institutions. These institutions have to recruit, teach, and put together a various STEM team of workers to improve the frontiers of science and participate within the U.S. technology-based mostly economy. NSF’s contribution to the countrywide innovation ecosystem is to deliver reducing-area analysis under the information of the Nation’s most creative scientists and engineers. NSF additionally supports development of a strong science, technology, engineering, and arithmetic (STEM) staff by investing in building the capabilities that informs advancements in STEM educating and studying.
NSF’s mission calls for the broadening of opportunities and expanding participation of organizations, associations, and geographic regions which are underrepresented in STEM disciplines, which is fundamental to the health and vitality of science and engineering. NSF is dedicated to this precept of variety and deems it imperative to the programs, projects, and activities it considers and helps.
A. benefit overview ideas and criteria
The countrywide Science groundwork strives to put money into a robust and distinct portfolio of tasks that creates new talents and makes it possible for breakthroughs in realizing throughout all areas of science and engineering analysis and training. To determine which projects to help, NSF relies on a benefit evaluation process that contains consideration of each the technical elements of a proposed project and its expertise to contribute greater commonly to advancing NSF’s mission "to advertise the growth of science; to boost the country wide fitness, prosperity, and welfare; to relaxed the countrywide defense; and for other functions." NSF makes every effort to behavior a good, competitive, transparent merit review system for the selection of tasks.
1. benefit overview concepts
These principles are to take delivery of due diligence via PIs and corporations when preparing proposals and managing projects, by using reviewers when reading and evaluating proposals, and through NSF program workforce when settling on even if or not to recommend proposals for funding and while overseeing awards. considering NSF is the simple federal company charged with nurturing and assisting excellence in simple analysis and education, right here three ideas follow:
All NSF tasks should be of the very best quality and have the advantage to improve, if no longer transform, the frontiers of abilities.
NSF tasks, in the mixture, may still contribute extra largely to reaching societal goals. These "Broader influences" may be achieved during the research itself, via actions that are without delay regarding selected research initiatives, or through actions that are supported via, but are complementary to, the mission. The mission activities can be in keeping with previously based and/or inventive strategies and strategies, however in both case have to be well justified.
significant evaluation and evaluation of NSF funded projects should still be in line with acceptable metrics, conserving in intellect the doubtless correlation between the effect of broader impacts and the substances offered to enforce projects. If the size of the exercise is restricted, assessment of that activity in isolation isn’t more likely to be significant. thus, assessing the effectiveness of those activities may most useful be completed at a higher, greater aggregated, stage than the individual assignment.
With admire to the third principle, although assessment of Broader influences results for particular projects is completed at an aggregated degree, PIs are anticipated to be in charge for carrying out the actions described in the funded venture. as a result, particular person tasks should still include obviously brought up desires, selected descriptions of the actions that the PI intends to do, and a plan in area to document the outputs of these actions.
These three advantage overview concepts supply the foundation for the merit evaluation criteria, in addition to a context inside which the clients of the criteria can better be mindful their intent.
2. benefit review criteria
All NSF proposals are evaluated through use of the two national Science Board permitted merit overview criteria. In some instances, despite the fact, NSF will employ further criteria as required to spotlight the specific goals of certain courses and activities.
both advantage overview standards are listed under. both criteria are to be given full consideration all over the evaluate and determination-making strategies; every criterion is indispensable but neither, by using itself, is adequate. hence, proposers should utterly handle each standards. (PAPPG Chapter II.C.2.d(i). consists of more information to be used by proposers in construction of the mission Description portion of the thought). Reviewers are strongly encouraged to assessment the standards, including PAPPG Chapter II.C.2.d(i), in advance of the evaluation of a thought.
When evaluating NSF proposals, reviewers may be asked to trust what the proposers are looking to do, why they want to do it, how they plan to do it, how they are going to recognize in the event that they be triumphant, and what advantages may accrue if the task is successful. These concerns practice each to the technical points of the proposal and the style during which the undertaking may additionally make broader contributions. To that end, reviewers may be asked to consider all proposals towards two criteria:
intellectual advantage: The highbrow merit criterion encompasses the advantage to boost advantage; and
Broader impacts: The Broader affects criterion encompasses the abilities to advantage society and make contributions to the fulfillment of selected, preferred societal effects.
right here facets should still be regarded within the assessment for each standards:
what is the capabilities for the proposed exercise to
increase skills and knowing within its personal field or throughout diverse fields (intellectual advantage); and
benefit society or advance desired societal consequences (Broader affects)?
To what extent do the proposed activities imply and explore artistic, original, or probably transformative ideas?
Is the plan for carrying out the proposed actions neatly-reasoned, smartly-organized, and based on a sound purpose? Does the plan incorporate a mechanism to determine success?
How neatly certified is the individual, team, or organization to habits the proposed activities?
Are there adequate elements accessible to the PI (either on the domestic firm or via collaborations) to carry out the proposed activities?
Broader impacts may well be completed throughout the analysis itself, throughout the actions which are directly regarding particular research initiatives, or via activities that are supported by using, but are complementary to, the assignment. NSF values the development of scientific advantage and activities that contribute to success of societally important effects. Such outcomes include, but are not restrained to: full participation of girls, humans with disabilities, and underrepresented minorities in science, know-how, engineering, and arithmetic (STEM); greater STEM training and educator construction at any stage; accelerated public scientific literacy and public engagement with science and technology; more desirable neatly-being of individuals in society; construction of a various, globally aggressive STEM personnel; increased partnerships between academia, trade, and others; improved national protection; expanded economic competitiveness of the U.S.; and more advantageous infrastructure for analysis and education.
Proposers are reminded that reviewers will also be asked to evaluate the information management Plan and the Postdoctoral Researcher Mentoring Plan, as acceptable.
extra Solicitation selected review standards
IUCRC center/web page Planning preliminary proposals are evaluated by using NSF software Officers and encouraged or discouraged in response to here:
The crucial value, strong point, and innovation of the research area and its potential national economic influence.
The size of the trade dedication helping the center.
The high-quality and inter-institutional participation in middle-proposed research projects.
website team readiness and plan for recruiting new industry members and keeping existing ones.
figuring out of the desires of the IUCRC program and an acceptable implementation plan.
proven independence of the proposed subject from present IUCRCs.
approach to attractive a diverse mix of industry participants, including companies (big and small), startups, non-income corporations, executive agencies, and/or different fascinated non-tutorial entities.
Full IUCRC Proposals
Full proposals are field to right here extra evaluation criteria:
For Planning, phase I, phase II, phase II+, and part III proposals:
The advantage for economic and societal impact;
The degree to which the trade membership and commitments to participate in the proposed IUCRC has been met or passed;
The diploma to which unmet or underserved industrial needs can be addressed by using slicing-edge, transformational pre-competitive analysis and the electricity of expertise industrial pastime;
The robustness of the plan to engage college students from groups historically underrepresented in STEM disciplines, and to assist and mentor underrepresented faculty, staff, and college students;
The dedication from faculty and the research infrastructure availability to hold a attainable core that attracts and retains industry individuals, and college success in center-connected analysis;
The effectiveness of the plans for synergistic integration and collaborative efforts of all websites in middle actions; and
The effectiveness of the planned middle and sites outreach activities in speaking with the public and core stakeholders, as well as trade.
moreover, for phase II, section II+, and section III proposals:
The extent to which potential/expertise transfer to contributors happens, the generation of recent intellectual Property (IP) from middle actions, and the plan to each spin out new groups and assist different new ventures in the sector of pastime;
The diploma of participation and contribution of middle stakeholders (i.e., IAB participants, college, students, etc.) at the biennial IAB conferences;
The quantity and first-class of alternatives offered to college students and postdocs to work carefully with industry mentors and IAB corporations, and the placement of scholars in IAB corporations or other groups in the sector;
The satisfactory and value of the analysis results and scientific accomplishments all over the prior phase; and
The degree to which the center met and surpassed the IUCRC monetary and membership requirements all the way through the prior phase.
B. assessment and choice system
Proposals submitted in line with this program solicitation should be reviewed through
advert hoc evaluate and/or Panel evaluation.
Reviewers should be asked to evaluate proposals the use of two country wide Science Board accredited benefit evaluation criteria and, if applicable, additional program particular criteria. A abstract ranking and accompanying narrative will frequently be accomplished and submitted by each and every reviewer and/or panel. The application Officer assigned to control the notion’s review will agree with the tips of reviewers and should formulate a recommendation.
After scientific, technical and programmatic assessment and consideration of acceptable elements, the NSF application Officer recommends to the cognizant Division Director whether the suggestion may still be declined or recommended for award. NSF strives to be in a position to tell applicants no matter if their proposals have been declined or counseled for funding within six months. tremendous or primarily complex proposals or proposals from new awardees may also require extra evaluation and processing time. The time interval starts on the cut-off date or target date, or receipt date, whichever is later. The interval ends when the Division Director acts upon the program Officer’s recommendation.
After programmatic approval has been acquired, the proposals suggested for funding can be forwarded to the Division of promises and Agreements for review of company, fiscal, and coverage implications. After an administrative review has happened, offers and Agreements Officers perform the processing and issuance of a provide or different settlement. Proposers are cautioned that best a promises and Agreements Officer may additionally make commitments, responsibilities or awards on behalf of NSF or authorize the expenditure of cash. No commitment on the a part of NSF should still be inferred from technical or budgetary discussions with a NSF software Officer. A fundamental Investigator or firm that makes economic or personnel commitments in the absence of a furnish or cooperative settlement signed by the NSF promises and Agreements Officer does so at their personal chance.
as soon as an award or declination resolution has been made, major Investigators are supplied feedback about their proposals. In all instances, stories are treated as personal documents. Verbatim copies of reviews, excluding the names of the reviewers or any reviewer-identifying guidance, are sent to the main Investigator/challenge Director by using the program Officer. furthermore, the proposer will acquire an explanation of the decision to award or decline funding.
VII. AWARD ADMINISTRATION tips
A. Notification of the Award
Notification of the award is made to the submitting firm via a supplies Officer in the Division of delivers and Agreements. organizations whose proposals are declined will be counseled as without delay as possible with the aid of the cognizant NSF application administering the software. Verbatim copies of studies, now not including the identification of the reviewer, could be supplied instantly to the foremost Investigator. (See section VI.B. for more information on the review process.)
B. Award conditions
An NSF award contains: (1) the award notice, which comprises any special provisions relevant to the award and any numbered amendments thereto; (2) the budget, which suggests the quantities, via categories of cost, on which NSF has primarily based its guide (or in any other case communicates any specific approvals or disapprovals of proposed bills); (3) the inspiration referenced in the award observe; (4) the relevant award conditions, such as provide normal situations (GC-1)*; or research phrases and stipulations* and (5) any announcement or different NSF issuance that could be included by reference in the award note. Cooperative agreements are also administered according to NSF Cooperative agreement financial and Administrative phrases and prerequisites (CA-FATC) and the relevant Programmatic phrases and conditions. NSF awards are electronically signed by means of an NSF delivers and Agreements Officer and transmitted electronically to the organization by way of e mail.
*These documents could be accessed electronically on NSF’s site at https://www.nsf.gov/awards/managing/award_conditions.jsp?org=NSF. Paper copies could be got from the NSF Publications Clearinghouse, mobile (703) 292-8134 or by using electronic mail from firstname.lastname@example.org.
greater finished counsel on NSF Award circumstances and other crucial tips on the administration of NSF awards is contained in the NSF proposal & Award policies & techniques ebook (PAPPG) Chapter VII, available electronically on the NSF web site at https://www.nsf.gov/publications/pub_summ.jsp?ods_key=pappg.
special Award circumstances:
For the purpose of the IUCRC program, NSF hereby clarifies that "challenge" is described as a center research endeavor. each and every site have to demonstrate in its annual document how NSF cash and program salary have furthered core desires and pursuits. It must additionally detail the volume and use of center dollars for the site’s personal administration and operations, for well-known center administrative activities, and for conducting IAB-approved analysis tasks at that web page.
Membership fees and other cash acquired with the aid of the core from members of its IAB are considered software income (https://www.nsf.gov/pubs/policydocs/pappg20_1/pappg_8.jsp#VIIID4):
application profits should still be used for IAB-counseled analysis projects and linked costs. at least ninety percent of the IUCRC software revenue need to be used to help direct charges of the research, and as much as 10 percent could be used to help oblique expenses. The core’s IAB can also vote on the allocation of application salary to guide middle administrative or non-research related prices with cognizant software Director approval.
For the IUCRC application, software earnings don’t need to be expended just before the use of federal money. although, no unexpended software profits might also continue to be at the conclusion of the award. Unexpended money must be remitted to NSF via crediting fees, in any other case chargeable in opposition t the provide. whether it is now not possible to listing the credit by the use of digital device (ACM$), excess software income must be remitted to NSF electronically or with the aid of check, payable to the countrywide Science foundation.
middle compliance with NSF necessities described in this solicitation (number of equivalent Full memberships and membership price total) might be assessed annually. If a center falls beneath the minimal membership requirements, it can be given a second 12 months to comply in the subsequent annual reporting length. If a middle continues to fall beneath minimum membership requirements for two consecutive years NSF might also initiate appropriate corrective moves. This may additionally include withholding future continuing provide increments for non-conforming websites/facilities and/or adjusting the end date of their awards.
If a web site is not contributing extensively on an annual basis to the middle, based on the number of initiatives and quantity of core funding it receives from engaged on IAB-connected projects, NSF may additionally provoke appropriate corrective moves. This may encompass withholding future continuing supply increments for underperforming websites and/or adjusting the end date of their awards.
a center in search of to transition from phase I to the next phase may be expected to fulfill each the required variety of equivalent Full memberships in addition to program salary from membership payment cash contributions on a cumulative basis over the period of the section I award. for instance, an N-web page IUCRC might be anticipated to existing 5 years x ($150,000 x N) of software revenue from membership expenses, and 5 years x (3 x N) equivalent full memberships summing throughout each 12 months of the grant.
as an example, a N=2 core with a Full membership level of $50,000/year has necessities of 6 Full memberships or equal as per table 1. If it continues equivalent Full memberships of 6, 5, 6, 6, 7 in Years 1, 2, three, 4, 5 respectively, the cumulative equivalent Full memberships would be 30 and the cumulative membership fees could be $1,500,000, and for this reason this core would meet the NSF requirement. besides the fact that children, if the middle maintained 6, 5, 6, 6, 6 equivalent Full memberships, it might fall short of the NSF requirement for both cumulative cash contributions as well as cumulative equal Full memberships and potentially be area to corrective motion.
If a Lead web site is found to be underperforming, NSF might also seek advice from the IAB and different website directors to explore the opportunity of altering core administrators and/or the Lead site designation.
C. Reporting necessities
For all multi-yr can provide (together with each general and carrying on with gives you), the major Investigator have to publish an annual assignment document to the cognizant program Officer no later than 90 days ahead of the end of the current funds duration. (Some programs or awards require submission of greater ordinary project studies). No later than 120 days following expiration of a grant, the PI also is required to submit a ultimate challenge file, and a assignment results record for the accepted public.
Failure to give the necessary annual or remaining challenge studies, or the mission results report, will extend NSF assessment and processing of any future funding increments as well as any pending proposals for all identified PIs and co-PIs on a given award. PIs may still examine the codecs of the necessary stories in enhance to guarantee availability of required statistics.
PIs are required to use NSF’s electronic project-reporting device, purchasable via analysis.gov, for education and submission of annual and last mission studies. Such reports supply counsel on accomplishments, assignment members (individual and organizational), publications, and other certain products and influences of the venture. Submission of the report via analysis.gov constitutes certification through the PI that the contents of the report are accurate and comprehensive. The undertaking results file also have to be organized and submitted the use of analysis.gov. This document serves as a brief summary, prepared particularly for the public, of the character and effects of the assignment. This document could be posted on the NSF web page exactly as it is submitted by way of the PI.
greater finished guidance on NSF Reporting necessities and other vital counsel on the administration of NSF awards is contained in the NSF concept & Award guidelines & techniques guide (PAPPG) Chapter VII, attainable electronically on the NSF website at https://www.nsf.gov/publications/pub_summ.jsp?ods_key=pappg.
further Reporting requirements:
IUCRC awards require additional reporting necessities. These necessities are at the moment present process the tips collection assessment technique and the clearance quantity could be protected with the reporting necessities. For updated assistance, PIs are encouraged to consult the IUCRC web page (https://www.nsf.gov/eng/iip/iucrc/home.jsp) just before submitting their annual stories.
VIII. company CONTACTS
Please note that the application contact suggestions is current on the time of publishing. See software web page for any updates to the facets of contact.
familiar inquiries involving this program should still be made to:
Prakash G. Balan,
IUCRC software Director, Directorate for Engineering,
electronic mail: email@example.com
Behrooz A. Shirazi,
IUCRC program Director, Directorate for desktop & advice Science & Engineering,
Ann C. Von Lehmen,
IUCRC application Director, Directorate for desktop & suggestions Science & Engineering,
e mail: firstname.lastname@example.org
IUCRC program Director, Directorate for Social, Behavioral & financial Sciences,
Barbara L. Ransom,
IUCRC software Director, Directorate for Geosciences,
electronic mail: email@example.com
For questions related to the use of FastLane or analysis.gov, contact:
FastLane and research.gov help Desk: 1-800-673-6188
FastLane assist Desk e mail: firstname.lastname@example.org.
analysis.gov help Desk electronic mail: email@example.com
For questions regarding can provide.gov contact:
offers.gov Contact center: If the approved Organizational Representatives (AOR) has not received a affirmation message from supplies.gov within 48 hours of submission of utility, please contact by way of phone: 1-800-518-4726; email: firstname.lastname@example.org.
be aware: For Directorates with topic-specific portfolios (i.e., Geosciences; Social, Behavioral, and financial Sciences), IUCRCs can be regarded simplest on subject matters of pastime dispensed by the use of dear Colleague Letters. Please assess the NSF web site or name the cognizant software Director for more information.
IX. different tips
The NSF site gives the most complete supply of assistance on NSF Directorates (together with contact information), classes and funding alternatives. Use of this web site by capabilities proposers is strongly inspired. moreover, "NSF replace" is an guidance-delivery equipment designed to retain competencies proposers and different involved events apprised of new NSF funding alternatives and publications, essential changes in suggestion and award policies and procedures, and upcoming NSF provides Conferences. Subscribers are counseled through e mail or the user’s net browser every time new publications are issued that suit their identified pursuits. "NSF replace" also is attainable on NSF’s website.
provides.gov provides an extra digital capacity to search for Federal government-large supply alternatives. NSF funding opportunities could be accessed via this mechanism. extra tips on offers.gov could be acquired at https://www.promises.gov.
about the country wide SCIENCE foundation
The countrywide Science foundation (NSF) is an impartial Federal agency created through the national Science foundation Act of 1950, as amended (42 USC 1861-75). The Act states the purpose of the NSF is "to advertise the progress of science; [and] to improve the national fitness, prosperity, and welfare through assisting analysis and schooling in all fields of science and engineering."
NSF money analysis and education in most fields of science and engineering. It does this through delivers and cooperative agreements to more than 2,000 schools, universities, okay-12 school techniques, groups, informal science businesses and other analysis groups during the U.S.. The groundwork bills for approximately one-fourth of Federal support to educational institutions for primary research.
NSF receives about 55,000 proposals every 12 months for research, education and practicing projects, of which approximately eleven,000 are funded. in addition, the groundwork receives a few thousand purposes for graduate and postdoctoral fellowships. The agency operates no laboratories itself however does help national research centers, user facilities, definite oceanographic vessels and Arctic and Antarctic analysis stations. The basis additionally supports cooperative research between universities and industry, US participation in international scientific and engineering efforts, and educational activities at each tutorial degree.
Facilitation Awards for Scientists and Engineers with Disabilities (FASED) give funding for special guidance or machine to allow individuals with disabilities to work on NSF-supported projects. See the NSF concept & Award policies & methods book Chapter II.E.6 for guidelines related to instruction of those styles of proposals.
The national Science basis has Telephonic gadget for the Deaf (TDD) and Federal information Relay service (FIRS) capabilities that allow people with listening to impairments to talk with the foundation about NSF classes, employment or prevalent tips. TDD can be accessed at (703) 292-5090 and (800) 281-8749, FIRS at (800) 877-8339.
The country wide Science basis assistance middle may well be reached at (703) 292-5111.
The countrywide Science basis promotes and advances scientific growth in the united states through competitively awarding can provide and cooperative agreements for research and education in the sciences, arithmetic, and engineering.
To get the newest guidance about program closing dates, to down load copies of NSF publications, and to access abstracts of awards, talk over with the NSF site at https://www.nsf.gov
2415 Eisenhower Avenue, Alexandria, VA 22314
For prevalent information(NSF advice core):
TDD (for the hearing-impaired):
To Order Publications or varieties:
ship an e mail to:
privacy ACT AND PUBLIC BURDEN STATEMENTS
The tips requested on thought varieties and mission stories is solicited under the authority of the countrywide Science basis Act of 1950, as amended. The counsel on proposal kinds can be used in connection with the selection of certified proposals; and venture studies submitted with the aid of awardees will be used for application assessment and reporting inside the executive branch and to Congress. The suggestions requested may well be disclosed to qualified reviewers and team of workers assistants as a part of the concept evaluation process; to proposer institutions/grantees to supply or acquire records concerning the concept evaluate technique, award selections, or the administration of awards; to government contractors, experts, volunteers and researchers and educators as vital to comprehensive assigned work; to other government agencies or different entities needing counsel regarding applicants or nominees as a part of a joint application evaluation method, or in an effort to coordinate classes or coverage; and to a different Federal company, court docket, or birthday party in a court docket or Federal administrative proceeding if the government is a party. counsel about fundamental Investigators may well be introduced to the Reviewer file and used to opt for expertise candidates to function peer reviewers or advisory committee members. See equipment of record Notices, NSF-50, "most important Investigator/proposal File and linked facts," and NSF-51, "Reviewer/suggestion File and associated records.” Submission of the guidance is voluntary. Failure to give full and comprehensive tips, despite the fact, may also in the reduction of the opportunity of receiving an award.
An agency may additionally now not behavior or sponsor, and an individual isn’t required to respond to, an assistance collection until it displays a legitimate office of administration and finances (OMB) manage number. The OMB control number for this assortment is 3145-0058. Public reporting burden for this collection of counsel is estimated to general one hundred twenty hours per response, together with the time for reviewing guidelines. ship feedback involving the burden estimate and every other aspect of this collection of counsel, including tips for decreasing this burden, to:
Suzanne H. Plimpton
studies Clearance Officer
office of the universal tips
national Science foundation
Alexandria, VA 22314